Management of Relapsed-Refractory Multiple Myeloma in the Era of Advanced Therapies: Evidence-Based Recommendations for Routine Clinical Practice. Bull Cancer. FDA/EMA Accept Ide-Cel Applications for Earlier R/R Multiple Myeloma Use. It is the first bispecific agent targeting the protein GPRC5d in multiple myeloma patients," Chari said. Teclistamab (Tecvayli) for the Treatment of Multiple Myeloma Generic Name. Overall, across all treatment groups the trial found 73% of subjects responded positively to the treatment. . A biologics license application has been submitted to the FDA for talquetamab for the treatment of patients with relapsed or refractory multiple myeloma. More than 30% of patients in both groups had a complete response or better, and nearly 60% had a very good partial response or better. [Bispecific antibodies in multiple myeloma]. The researchers said very few patients (5 to 6 percent) stopped talquetamab treatment because of side effects. The response rate observed in the study, which Chari explained is higher than that for most . Data showed skin- and taste-related side effects were common, but typically rated mild. Recent advances in the treatment of multiple myeloma The immunotherapy being trialled is called talquetamab. Grade ranged from grade 1 to grade 3 for the dermatologic events. Talquetamab appears to have a have favorable risk/benefit profile in RRMM with durable responses and manageable toxicities. The bottom line is that almost 70% of heavily pre-treated triple+ refractory patients responded! doi: 10.1016/j.bulcan.2021.10.003. The drug produced a substantial response, with only low-grade side effects, in 70% of the patients. "It seems the total effect is a real drying effect. . The Expanding Clinical Role of Bifunctional Antibodies. Taltz | European Medicines Agency technology has been in development for decades, Rewired genetic 'clock' slows aging and increases cellular lifespan, Surfcycle: A highway-speed, lane-splitting stand-up scooter on steroids, Astronomers spot nearest star-destroying black hole. Additionally, updated results show that 31 of 32 patients in the pivotal portion of lovo-cels trial havent had a painful episode known as a vaso-occlusive crisis through at least two years of follow-up. Only one patient to date at our center, has discontinued treatment due to an oral or dermatologic side effect. DrugBank Accession Number. Lindsay Diamond, MSN, AGNP-C, AOCNP, discusses findings from CheckMate 274 and other data presented during the 2023 ASCO Genitourinary Cancers Symposium. MNT is the registered trade mark of Healthline Media. Clin Lymphoma Myeloma Leuk. Oral TEAEs were common in the trial with 57.9% of patients (n = 44) experiencing a grade 1 or 2 oral AE. Additionally, Shain said that patients on other BiTE therapies may experience an increased risk of infection, as well as rashes, nail issues, loss of taste and other side effects all of which should be brought up to the health care team to ensure that patients can remain on therapy. Its encouraging to see results from trials which indicate that talquetamab could be used to treat myeloma, but further studies are needed before it can be used in the clinic..

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