In developing his recommendations, he used cross-species comparisons, evolutionary arguments, the concept of biochemical individuality, and the amount of vitamin C likely consumed in a raw plant food diet. (PubMed), 51. 2013;33:45-70. 2008;105(32):11105-11109. (PubMed), 121. Collagen is required to keep our arteries flexible and strong. Eur J Clin Invest. In: Packer L, Fuchs J, eds. (PubMed), 111. It is not intended as nutritional or medical advice for individual problems. Anderson R, Oosthuizen R, Maritz R, Theron A, Van Rensburg AJ. Therefore, as in many studies of vitamin C intake and chronic disease risk, it is difficult to separate the effects of vitamin C from the effects of other components of fruit and vegetables. Scientific studies investigating vitamin C efficacy to prevent or treat disease need to assess baseline vitamin C status before embarking on an intervention or statistical analysis (22, 29-31). University of Otago Calcium ascorbate: Calcium ascorbate generally provides 90-110 mg of calcium (890-910 mg of ascorbic acid) per 1,000 mg of calcium ascorbate. Dingchao H, Zhiduan Q, Liye H, Xiaodong F. The protective effects of high-dose ascorbic acid on myocardium against reperfusion injury during and after cardiopulmonary bypass. Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. Curr Opin Crit Care. Harding AH, Wareham NJ, Bingham SA, et al. While most generally healthy young adults can achieve these plasma concentrations with daily vitamin C intake of at least 200 mg/day, some individuals may have a lower vitamin C absorptive capacity than what is currently documented. There is a need for larger, longer-duration phase II clinical trials that test the efficacy of intravenous vitamin C in disease progression and overall survival (176). The information is made available with the understanding that the author and publisher are not providing medical, psychological, or nutritional counseling services on this site. In addition, there is currently little evidence to support a role for vitamin C in the management of patients with gout (123). (PubMed), 108. 2011;43(6):624-627. Heart Disease Vitamin C and Linus Pauling by Jeffrey Dach MD 2010;19(5):360-365. Vitamin C supplements are available in many forms, but there is little scientific evidence that any one form is better absorbed or more effective than another. The recommended intake for smokers is 35 mg/day higher than for nonsmokers, because smokers are under increased oxidative stress from the toxins in cigarette smoke and generally have lower blood concentrations of vitamin C (36). (PubMed), 157. 1997;15(6):795-801. Reversal of ionoregulatory disruptions in occupational lead exposure by vitamin C. Environ Toxicol Pharmacol. The effect of ascorbic acid supplementation on the blood lead levels of smokers. Contents Summary Function Playing in immunity Bioavailability Deficiency Aforementioned RDA Disease Prevention Cardio-vascular disease Cancer Print 2 diabetes mellitus Adverse pregnancy outcomes (PubMed), 89. (PubMed), 12. Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials. These contradictory findings indicate that further research is needed on potential interactions between antioxidant supplements and cholesterol-lowering drugs, such as HMG-CoA reductase inhibitors (statins). Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health. PaulingTherapy.com - Reversing Heart Disease w/o Drugs is Possible By pooling data from 13 prospective cohort studies comprising 676,141 participants, it was determined that dietary intake of vitamin C was not associated with colon cancer, while total intake of vitamin C (i.e., from food and supplements) was associated with a 19% reduced risk of colon cancer (79). Spoelstra-de Man AME, Elbers PWG, Oudemans-Van Straaten HM. (PubMed), 133. 2011;63(9):1295-1306. Although ascorbyl palmitate is also available as an oral supplement, most of it is likely hydrolyzed to ascorbic acid and palmitic acid in the digestive tract before it is absorbed (189). Alexander J. Michels, Ph.D. The mechanisms underlying differential sensitivity to vitamin C are under investigation. 2014;4:283. (PubMed), 25. 2017;71(12):1371-1380. Goodman M, Bostick RM, Kucuk O, Jones DP. Ascorbic acid and rates of cognitive decline in Alzheimer's disease. Hypertension. Age-related changes to the lens (thickening, loss of flexibility) and oxidative damage contribute to the formation of cataract, i.e., cloudiness or opacity in the lens that interferes with the clear focusing of images on the retina.

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