Reply. School of Pharmacy, Faculty of Life Sciences, University College London, United Kingdom. Statistical analysis was performed with Stata 14 software (Stata Corporation, College Station, TX, USA). Liu-Cheng Li was responsible for drafting the manuscript. [citation needed]. (Jinyinhua), Ephedra sinica Stapf (Mahuang), Armeniacae Amarum Semen (Kuxingren), Gypsum Fibrosuum (Shigao), Isatis tinctoria L. (Banlangen), Dryopteridis Crassirhizomatis Rhizoma (Mianmaguanzhong), Houttuynia cordata Thunb. Chin. Inhibitory effects of three prescriptions of traditional Chinese medicine on SARS-associated coronavirus, http://kns.cnki.net/kcms/detail/11.2162.R.20200422.1429.002.html. Moreover, LHQW capsule also remarkably decreased the infectivity of H3N2 in vitro [25]. The LHQW group has a reduced incidence of gastrointestinal system damage than the conventional drug group (RR = 0.83, 95% CI = 0.740.93, p = 0.002). It warned that sellers who make claims that it can prevent, protect against or treat COVID-19 may face prosecution. This work was supported by the National Natural Science Foundation of China (No. COVID-19 pandemic has caused a serious threat to public health and become the greatest challenge facing the world. 52 (3), 5860. (japanese honeysuckle) flower 27.41 mg, gypsu . Our findings support the adverse reactions recorded by Yiling Pharmaceutical, and compare the incidence risk of gastrointestinal system damage and rash with the control group. Clinical effectiveness and case analysis in 54 NCP patients treated with Lanhuaqingwen granules. The most common adverse reactions in our analysis were gastrointestinal system damage, skin and its appendage damage. In recent years, LHQW has played a significant role in the prevention and control of viral public health events (Yao et al., 2020), and is widely accepted as a representative antiviral Chinese medicine in China. doi:10.1111/j.1365-2796.1990.tb00199.x, Higgins, J. P., Altman, D. G., Gtzsche, P. C., Jni, P., Moher, D., Oxman, A. D., et al. Exploring material basis and mechanism of Lianhua Qingwen prescription against coronavirus based on network pharmacology. The authors report no declarations of interest. Lianhua Qingwen capsule/granule (LHQW) is obtained by combining Ma Xing Shigan Decoction with Yinqiao Powder and widely used in the clinical treatment of respiratory disorders (Liu et al., 2010). doi:10.19803/j.1672-8629.2015.12.011, Rivera, D., Allkin, R., Obn, C., Alcaraz, F., Verpoorte, R., and Heinrich, M. (2014). Dong L., Xia J.W., Gong Y., Chen Z., Yang H.H., Zhang J., He J., Chen X.D. BMJ. (2020) identified 38 randomized controlled trials (RCTs) comparing LHQW with antivirals or other Chinese medicines for treating influenza and reported a lower risk of adverse reactions in the LHQW group compared to oseltamivir (RR = 0.29, 95%CI = 0.110.80), and ribavirin groups (RR = 0.29, 95%CI = 0.110.80). In a lipopolysaccharide (LPS)-induced acute lung injury animal model, LHQW could efficiently decrease the chemotaxis of monocytes toward the pulmonary infection foci, and thus blocked the disease development by down-regulating MCP-1 expression [33]. Res. Available at: http://www.yiling.cn/contents/75/132.html (Accessed September 14, 2021). Evid. There was a reduced risk of skin and its appendage damage in the LHQW group compared to the conventional drug group (RR = 0.63, 95% CI = 0.440.92, p = 0.015). 2017ZYY07). (2020). However, the efficacy and safety of which shall be confirmed by more high-quality clinical trials. Lianhua Qingwen Capsules/granules Product Details. However, both groups did not differ in the rate of conversion to severe cases or viral assay findings. Efficacy of Lianhua Qingwen Compared With Conventional Drugs in the Treatment of Common Pneumonia and Covid-19 Pneumonia: a Meta-Analysis. The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author. (2015). Hence, the researches on specific active components of LHQW are still important and the reduction of irrelevant ingredients may be related to less adverse reactions. aimed to assess the efficacy and safety of LH combined with usual treatment vs usual treatment alone in treating mild or moderate COVID-19 by a meta-analysis of randomized controlled trials (RCTs). J. Chin. Vahl [Oleaceae; Forsythiae Fructus] (255g), Lonicera japonica Thunb. Moher, D., Liberati, A., Tetzlaff, J., and Altman, D. G.PRISMA Group (2009). Keywords: Mo H.Y., Ke C.W., Zheng J.P., Zhong N.S. (2020). Lianhua Qingwen prescription for Coronavirus disease 2019 (COVID-19 Tian S., Song X., Wang Y., Wang X., Mou Y., Chen Q., Zhao H., Ma K., Wu Z., Yu H., Han X., Wang H., Wang S., Ji X., Zhang Y. Chinese herbal medicine Baoyuan Jiedu decoction inhibits the accumulation of myeloid derived suppressor cells in pre-metastatic niche of lung via TGF-/CCL9 pathway. To protect the interests of patients, the risk-benefit ratio of the drug needs to be considered in clinical applications. Beggs test and Eggers test detected no visible publication bias for data from pooled studies and disease evaluation. "It's the first time in the world that we have enough evidence to prove Lianhua Qingwen capsule is effective and can help . 343, d5928. Pharmacol. Chinese supplement Lianhua Qingwen: What you need to know Some composition of LHQW can cause damage to the stomach and intestines, supporting the possibility of injurious effects on the gastrointestinal system: for thia suspensa (Thunb.) Methods: Comprehensive document retrieval was performed from both English and Chinese databases. Lianhua Qingwen, the FDA-approved traditional Chinese med, only treats Due to the inclusion of Ephedra people with high blood pressure, anxiety, history of seizures, irregular heart beats, or other heart heart conditions, should avoid taking Linhua Quingwen. This study provides a basis for establishing the clinical safety profile of LHQW. Adverse Drug Reactions to Antibiotics Observed in Two Pulmonology Divisions of Catanzaro, Italy: a Six-Year Retrospective Study. [Lamiaceae; 1-Menthol] (7.5g), Glycyrrhiza uralensis Fisch. 8600 Rockville Pike Recent clinical evidence also showed that LHQW in combination with western medicines, such as the other antiviral drugs, is better than that not using LHQW during COVID-19 treatment, suggesting it would be beneficial as a supplementary strategy for treating COVID-19 [41,[44], [45], [46]]. 56 (2), 455463.

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