Expert Opin Drug Saf (2003) 2(6):597607.10.1517/14740338.2.6.597 doi: 10.1200/JCO.2009.25.7519, Schwartz, J. R., Bandera, C., Bradley, A., Brard, L., Legare, R., Granai, C. O., et al. All funding for this site is provided directly by ESMO. Cisplatinum rechallenge in relapsed ovarian cancer patients with platinum reinduction therapy and carboplatin hypersensitivity. J. Clin. Previous data indicated that prior carboplatin exposure is the primary risk factor for carboplatin-related hypersensitivity reactions among all patients (Navo et al., 2006; Koshiba et al., 2009). We also found higher rates of hypersensitivity among patients with malignant ascites compared to patients without malignant ascites (P = 0.009, chi-squared test), and in patients who had experienced allergic reactions to other medications or food (e.g., paclitaxel, penicillin, aspirin) compared to patients who had not experienced previous allergic reactions (P < 0.001, chi-squared test). ESMO is a Swiss-registered not-for-profit organisation. DARMSTADT, Germany, August 31, 2017 /PRNewswire/ --Not intended for U.K. or U.S. based media ESMO 2017 abstract #Erbitux: 576P, 593P, 1068P, 1579. Epub 2022 Nov 29. We performed tests on occupational exposure (from 10 different health care surfaces) from three types of chemotherapy (Cyclophosphamide, Gemcitabine and Fluorouracil) from three different hospitals in Sweden. It would be worthwhile to evaluate the correlation between other HRD genes and carboplatin hypersensitivity. The symptoms and signs of the 75 women with carboplatin-related hypersensitivity reactions are given in Table 4. Clinical practice guidance in a modernised format that focuses on visual representation of recommendations for quick and easy reference by practicing clinicians. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Authors S Rosell 1 , I Blasco 1 , L Garca Fabregat 1 , A Cervantes 1 , K Jordan 2 ; ESMO Guidelines Committee Clin Rev Allergy Immunol. Drafting of manuscript: Y-HT and W-FC. The comparison between other countries and ours about characteristics of the patients receiving carboplatin-based chemotherapy and risk factors of carboplatin-related hypersensitivity reactions. The histological type was serous in 381 patients (51.8%) and clear cell in 148 patients (20.1%). Table 2. These patients were provided with intravenous fluid infusion and medications, including corticosteroids, antihistamines, and oxygen application. 2017 Nov 8;8:1472. doi: 10.3389/fimmu.2017.01472. The cumulative incidence of severe carboplatin-related hypersensitivity was 1% after 15 cycles and 2% after 24 cycles, with a plateau beyond this cycle number, and 1% at >7,500 mg and 2% at >12,500 mg, with a plateau beyond this dose (Figures 1A,B ). Altwerger et al. (2016). It would be worthwhile to design a perspective trial that could randomize patients with carboplatin hypersensitivity to receive an alternative regimen without carboplatin. In the majority of ovarian cancer cases, primary management entails surgical staging or cytoreduction, followed by systemic chemotherapy (Ledermann et al., 2013). Interactive/Pocket Guideline Interactive/Pocket Guideline Constipation in Advanced Cancer 1 2 3 To assist those using and/or evaluating the ESMO Guidelines, download the methodology here, Download the new version of our App with the latest Pocket Guidelines for oncology professionals. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Allergy Asthma Proc (2011) 32(1):79.10.2500/aap.2011.32.3409 Evaluating whether any factors can predict carboplatin hypersensitivity, we identified a high correlation with the carboplatin cycle and cumulative dose (Pearson correlation coefficient 0.9318). PMC 17 This dose reduction is due to the ability of both aprepitant and netupitant to inhibit the metabolism of dexamethasone leading to higher . Summary format including algorithms, figures andtables for your presentations. These recommendations aim to develop guidance to mitigate the negative effects of the COVID-19 pandemic on the diagnosis and treatment of cancer patients. Ann. J. Clin. The cumulative incidence of carboplatin-related hypersensitivity was 2% at >3,500 mg, 6% at >7,500 mg, 8% at >10,000 mg, and 10% at >16,000 mg with a plateau beyond this dose (Figure 1B). No use, distribution or reproduction is permitted which does not comply with these terms. Such reactions could potentially be reduced or prevented by slowing the infusion rate and using a desensitization protocol involving anti-allergy medications. eCollection 2017. 3, 10 In subsequent trials, 11 - 16 patients were premedicated Utilizing Biologics in Drug Desensitization. View the photographic highlights from ESMO 2017 here! 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