After slow IV injection (given over 30 seconds for INFeD or 5 minutes for Dexferrum) or IM injection (INFeD) of 25 mg of iron (0.5 mL), observe for 1 hour for sensitivity reactions (see Anaphylaxis under Cautions) before administering the remaining portion of the initial dose. . endstream endobj 35 0 obj<> endobj 36 0 obj<> endobj 37 0 obj<>/Font<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 38 0 obj<> endobj 39 0 obj<> endobj 40 0 obj<> endobj 41 0 obj<> endobj 42 0 obj<> endobj 43 0 obj[/ICCBased 66 0 R] endobj 44 0 obj<> endobj 45 0 obj<>stream Based on the above factors, individuals with normal hemoglobin levels will have approximately 33 mg of blood iron per kilogram of body weight (15 mg/lb). . 0000003913 00000 n Normal hemoglobin (males and females) To avoid injection or leakage into the subcutaneous tissue, a Z-track technique (displacement of the skin laterally prior to injection) is recommended. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. endstream endobj 48 0 obj<> endobj 49 0 obj<> endobj 50 0 obj<> endobj 51 0 obj<>stream Bullock L, Parks RB, Lampasona V, Mullins RE. Generic name: iron dextran Such reactions may be immediate or delayed. Possible increased incidence of adverse effects, especially delayed reactions, associated with large IV doses of iron dextran, such as those used in total-dose infusions. fBw2e5/6k&Dd:/7(lc\s56l<6E'0$tumU? W@mZ_$3ZwE]^ . 5.4 Iron Overload (See Sensitivity Testing under Dosage and Administration.) INFeD, Dexferrum (iron dextran complex) dosing, indications - Medscape Dosage form: injection 6Ee^2+G8"c+TepPRb d_@ KAAtAP%$ 1GvuK h|Sqm!5x:9>{HBBL9x`:}R/{H$\SRH'yVf3g1EG5=p2a[\K5E:/mV: T1 Use of 5% dextrose injection instead of 0.9% sodium chloride injection may be associated with a higher incidence of local pain and phlebitis. Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as concomitant illnesses. 12.1 Mechanism of Action 0000001071 00000 n To avoid injection or leakage into subcutaneous tissue, use Z-track injection technique (i.e., firmly push aside subcutaneous tissue over the site of injection before inserting the needle). Your comment will be reviewed and published at the journal's discretion. Note: Patients using beta-blocking agents may not respond adequately to epinephrine. Please enable it to take advantage of the complete set of features! 1986 Jul-Aug;40(4):142-63. N}F( 9N(i{:%NISD;%NIS*T1 INFeD preparation: Administer by deep IM injection using a 2- or 3-inch, 19- or 20-gauge needle into the upper outer quadrant of the buttock only. The following information about each drug is given in tabular format: drug to be reconstituted and size of package; recommended route(s) of administration; recommended diluent, quantity to be used and resultant concentration; There have been several reports in the literature describing tumors at the injection site in humans who had previously received intramuscular injections of iron-carbohydrate complexes. Iron storage parameters may improve prior to hematologic parameters. Infed is not recommended for use in infants under 4 months of age [see Dosage and Administration (2.2)]. Factors contributing to the formula are shown below. PDF VACCINE PREPARATION AND ADMINISTRATION (Post in Vaccine Prep - Michigan Copyright 2023, Selected Revisions November 4, 2013. . 0000002019 00000 n In patients with CKD receiving an ESA, administer sufficient iron to maintain selected targets of iron therapy (i.e., transferrin saturation and serum ferritin concentrations); periodically monitor these iron indices and use results (in conjunction with hemoglobin concentrations and ESA dosage) to guide iron therapy. 0000036574 00000 n 4. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. If undiluted, administer by slow IV injection at 50 mg/minute (1 mL/minute). RRd::||7?_EeYU2&*[-%yWU0J@eZZ+)_P2B A_`T Each days dose should ordinarily not exceed 0.5 mL (25 mg of iron) for infants under 5 kg (11 lbs); 1.0 mL (50 mg of iron) for children under 10 kg (22 lbs); and 2.0 mL (100 mg of iron) for other patients. David McAuley, Pharm.D. 0000003396 00000 n Y-site compatibility of medications with parenteral nutrition. xb```f``= @Q#3108-. . The half-life of total iron, including both circulating and bound, is approximately 20 hours. Fatal reactions have occurred following a test dose of iron dextran and also in patients in whom the test dose was tolerated. 8.1 Pregnancy After reconstitution with 19 ml water for injections, the product contains 10 mg/ml voriconazole and 160 mg/ml SBECD. 8600 Rockville Pike 1972;9:94-98. J Pain Palliat Care Pharmacother. Ling J, Gupta VD. 1 0 obj Initial U.S. Approval: 1974 Development and operation of a pharmacy-based intravenous cytotoxic reconstitution service. the 6 time points after injection.15 A 94-subject rater-blinded randomized control study of EDP action potentials compared toxin used within 2 hours, 72 hours, 1, 2, 3, or 4 weeks after reconstitution; at 1 week after injection, the point of maximum effect, there was no difference in quantitative paralysis . Stability of ranitidine hydrochloride and amino acids in parenteral nutrient solutions. 0000035692 00000 n 0000010567 00000 n Increased Risk of Toxicity in Patients with Underlying Conditions ],kI#tp. INFeD is indicated for treatment of adult and pediatric patients of age 4 months and older with documented iron deficiency who have intolerance to oral iron or have had an unsatisfactory response. 0000004098 00000 n Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Use only in patients in whom a clearly established indication for parenteral iron therapy exists, confirmed by appropriate clinical and laboratory tests. Administer test dose prior to first therapeutic dose. 0000001797 00000 n PDF Significance of Reconstitution Time and Other Physical Parameters for

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